In a communique, the Latin American leader demanded that the US explain its motives in “financing, promoting and defending members of the opposition that promote violence against our country.”

Maduro went on to denounce declarations made by President Obama regarding the situation in Venezuela, saying that they presented a “gross interference in internal affairs.”

The new accusations come amidst a spike in the unrest that has gripped Venezuela, with some six people killed since demonstrations mounted by the opposition turned violent last week.

Wednesday night saw sporadic clashes between demonstrators in the capital of Caracas, the majority of which are middle class students who are frustrated with the country’s sputtering economy and soaring crime rate, and are seeking a regime change.

Maduro, who was elected last year as the heir apparent following the death of long-time President Hugo Chavez, has accused the opposition of fomenting a coup and inciting violence.

"There is an international campaign to justify a foreign intervention in Venezuela," Maduro said on Wednesday.

Members of the Venezuelan opposition have appealed to the international community over what they say was a tainted election, though little has been presented in the way of evidence of electoral impropriety in what was a closely contested runoff. Spearheading that effort has been Henrique Capriles, the opposition's two-time losing presidential candidate.

Venezuela’s ruling party, meanwhile, has long maintained that the US is playing a role in propping up the country’s opposition, and seeking to subvert the Maduro administration. That vitriol was sustained during Hugo Chavez’s tenure as the country’s leader; he often referred to an unsuccessful 2002 coup which heavily implicated US coordination.

The latest spout of violence came on the heels of opposition leader Leopoldo Lopez’s surrender to government authorities during a large rally in Caracas. Lopez, who has recently become a rising star among Maduro opponents, is alleged to have played a role in the 2002 coup attempt.

Lopez, the Harvard educated 42-year-old leader of the Popular Will party and a former mayor, is being held responsible for the casualties that have resulted as demonstrators continue to clash with government forces.

"I said, 'Send him to jail,' and that's what happened and that's what will happen with all of the fascists. I won't allow him to challenge the people of Venezuela, the constitution,” said Maduro shortly after his arrest.

Lopez is being held in Caracas' Ramo Verde military jail on charges of fomenting the violence. According to his lawyers, prosecutors have dropped the most serious charges of murder against him.